In this study we noted: (a) intravesical ALT-803 was safe and well tolerated alone and in combination with BCG, (b) as a single treatment agent, ALT-803 reduced tumor burden by 35% compared to a tumor reduction of 15% with BCG alone, (c) combination of ALT-803 plus BCG reduced tumor burden by 46% compared to control and was associated with natural killer (NK) cell activation [6]. This evidence concerns the gene GPT and neoplasm.