The etiopathogenetic mechanism of SAPHO syndrome, although having been proposed involving bacteriologic, immunologic and genetic factors [3] such as autophagy, interleukin-1(IL-1), Forkhead Box O1(FoxO1) and propionibacterium (Cutibacterium) acnes [9], remains poorly understood. The gene discussed is FOXO1; the disease is SAPHO syndrome.