PDPN is also upregulated in a variety of neoplasms, including colorectal tumors [9], squamous cell carcinomas [5, 6, 10, 11], mesothelioma [12], testicular seminoma [13], brain tumors [14–16] and some types of vascular tumors [17, 18] as well as in some papillary thyroid tumors [19]. The gene discussed is PDPN; the disease is squamous cell carcinoma.