Decreases in BACH2 mRNA expression were greater in CD4+ and CD8+ T-cells, as well as leukemic B-cell subpopulations from untreated CLL patient blood, compared with age-matched HDs (p = 0.0006; 0.0003 and 0.0083, respectively) (Fig. 4a). Here, BACH2 is linked to B-cell chronic lymphocytic leukemia.