CD4 and AIDS: A previous AIDS-event (versus none, mean difference in change − 3.40 cells/μL, 95% CI -5.09; − 1.71; p < 0.001) and baseline CD4 count (per 100 cells/μL higher, mean difference in change: − 98.41 cells/μL, 95% CI -98.72; − 98.11; p < 0.001) independently predicted CD4 change at week 48, after adjusting for type of dual regimen and nadir CD4 count.