Our in-silico analysis of TCGA and microarray expression databases indicated that although normal skin samples have a basal expression of PANX1, the transcript levels are significantly increased in primary melanoma tumors as shown on Figure 1A. However, once the expression of PANX1 is upregulated in primary melanoma, it does not seem to change significantly throughout the disease progression, from the T1 stage to advanced T3 stages (Figure 1B), although these conclusions would require analyses of larger sample numbers for confirmation. This evidence concerns the gene PANX1 and melanoma.