BTG3 and systemic sclerosis: Some of the consequences of this immune deregulation, include: the presence of auto-antibodies, mainly antinuclear (ANA), anticentromere (ACA), and antitopoisomerase (Scl70); the activation of circulating monocytes and the elevated infiltration of macrophages in the affected tissue of SSc patients; and altering of T cell homeostasis, leading to the elevated frequency of Th2 and Th17 cells observed in the peripheral blood and skin of SSc patients [40,41,45,46,47,48,49].