Interestingly, Sema3A stimulation induces the expression of FoxP3 in Breg cells from HC and SLE patients, but reduces the expression of Toll-like receptor 9 (TLR9) by total B cells of SLE patients, suggesting an immunoregulatory role of Sema3A in the pathology of the disease [71,73]. Here, FOXP3 is linked to systemic lupus erythematosus.