In addition, Sema3A levels negatively correlate with the Systemic Lupus Erythematosus Disease Activity Index (SLADAI), and lower serum levels of Sema3A are associated with kidney involvement and presence of anti-cardiolipin antibodies, which are risk markers for thrombotic events in SLE patients [71]. The gene discussed is SEMA3A; the disease is systemic lupus erythematosus.