In HeLa cervical cancer cell line, γ-T3 and δ-T3 induces ER stress via the activation of IRE1 pathway, which in turn mediates the alternative splicing of X-box binding protein 1 (XBP-1) mRNA and modulates CHOP transcription [70], leading to subsequent activation of caspase-9, -8, and -12 [70]. The gene discussed is XBP1; the disease is cervical cancer.