Laboratory tests, including assessment of white blood cell counts and serum C-reactive protein levels may be useful, as inflammatory markers are generally higher in children with SROIs than in those with peri-orbital cellulitis unrelated to complicated rhinosinusitis; it has also been reported that the presence of fever, a white blood cell count of >11,100 per microlitre, and proptosis are independent predictors of SPA or OA [31]. This evidence concerns the gene CRP and common cold.