Additionally, NU-0129, a spherical nucleic acid gold nanoparticle containing siRNAs targeting Bcl-2-like protein 12 (Bcl2L12), which is involved in tumor progression and resistance to apoptosis [62], is in early phase 1 clinical trials for patients with recurrent glioblastoma or gliosarcoma. The gene discussed is BCL2L12; the disease is gliosarcoma.