In summary, this is the first study reporting that AZD1208 has a cytostatic effect in human liposarcoma cells, which is be mediated through control of the expression and/or phosphorylation of Pim kinases, 4EBP-1, mTOR, S6, eIF-2α, STAT-3 and AMPK. Here, EIF4EBP1 is linked to liposarcoma.