RPS6KB1 and acute myeloid leukemia: Of further note, there is a recent study demonstrating that AZD1208 suppresses mTOR signaling, including inhibition of phosphorylation of mTOR (S2448), p70S6K (T389), S6 (S235/236) and 4EBP-1 (S65), in AML cell lines, which contribute to AZD1208’s cytostatic effects [9].