In MM, an autoregulatory loop between the miR-194-2-192 cluster and p53 has been discovered, in which p53 acts as a transcriptional activator of pri-miR-194-2 by directly binding to its core promoter element, and those miRNAs directly target 3′UTR of TP53 [28]. The gene discussed is TP53; the disease is Miyoshi myopathy.