Adenosine monophosphate is dephosphorylated to adenosine by the extracellular ectonucleotidase CD73, which is highly expressed on the plasma membrane of cancer and immune cells [39] Adenosine can then bind with the adenosine A2A receptor (A2AR) to exert immunosuppressive effects on the tumor microenvironment. Here, ADORA2A is linked to cancer.