Among the most enriched GO categories are “Chromatin Assembly”, “Chromatin Organization” and “DNA Metabolic Process”, including the genes encoding histone variants H2AX, essential for DNA repair and linked to chemoresistance in breast cancer [44] and H2AZ, whose high expression correlates with BC progression, lymph node metastasis and survival [45]. The gene discussed is H2AZ1; the disease is breast carcinoma.