These lncRNAs can be either upregulated (e.g., ANRIL, SNHG12, NEAT1 in some cancers, PVT1) or downregulated (e.g., GAS5, NEAT1 in APL) in order to promote cell proliferation and migration, and prevent apoptosis of cancerous cells [195,205,206,209]. The gene discussed is CDKN2B-AS1; the disease is cancer.