Previous studies showed that KRAS was regulated by several miRNAs, including let-7, miR-16, miR-143, and miR-1298 in breast cancer cells; miR-4689 in colon cancer; and miR-193b in PDAC cells.53, 54, 55, 56 In the current study, we demonstrated that miR-873 is a clinically significant miRNA and reduced expression of miR-873 is associated with significantly reduced overall survival, whereas restoration of miR-873 expression decreases cell proliferation, migration and invasion, and tumorigenesis by downregulating KRAS expression levels in PDAC and TNBC tumor models. This evidence concerns the gene KRAS and malignant colon neoplasm.