Oncogenic KRAS promotes pancreatic tumorigenesis through the activation of multiple downstream pathways, including RAF/MEK/ERK, MAPK, PI3K/Akt, Bad, and nuclear factor κB (NF-κB).41, 42 Inhibition of KRAS and its downstream pathways has been shown to reduce tumor growth and enhance gemcitabine chemotherapeutic efficacy against pancreatic cancer.43, 44 Downstream effectors of KRAS signaling in pancreatic cancer have been widely explored. The gene discussed is NFKB1; the disease is familial pancreatic carcinoma.