KRAS and colonic neoplasm: Previous studies showed that KRAS was regulated by several miRNAs, including let-7, miR-16, miR-143, and miR-1298 in breast cancer cells; miR-4689 in colon cancer; and miR-193b in PDAC cells.53, 54, 55, 56 In the current study, we demonstrated that miR-873 is a clinically significant miRNA and reduced expression of miR-873 is associated with significantly reduced overall survival, whereas restoration of miR-873 expression decreases cell proliferation, migration and invasion, and tumorigenesis by downregulating KRAS expression levels in PDAC and TNBC tumor models.