Shank3 mutations are strongly implicated as a monogenic cause of autism, and are central to the chromosome 22q13.3 deletion which causes Phelan‐McDermid syndrome, a neurodevelopmental disorder presenting with intellectual impairments, seizures, and autism [Durand et al., 2007; Betancur & Buxbaum, 2013; Monteiro & Feng, 2017]. Here, SHANK3 is linked to autism.