Finally, when comparing the diagnostic potential for the discrimination between CCA and PSC of the different miRNAs with established CCA tumor markers, ROC curve analysis showed that miR-122 (AUC: 0.818) had a slightly higher AUC value compared to CA19-9 (AUC: 0.778) and CEA (AUC: 0.774), while miR-192 had a comparable AUC value (0.753) (Fig 2F). The gene discussed is CEACAM5; the disease is cholangiocarcinoma.