AKT1 and breast cancer: The characteristics of the mutations found by target sequencing of the 8-gene panel were similar to those observed in other series of BC, with classical hotpots found in AKT1 and PIK3CA, a majority of missense mutations found in TP53, a higher proportion of truncating TP53 mutations in TN cases compared with other subtypes, and an expected distribution of mutated genes within IHC subtypes.