HSPA5 and neoplasm: Although descriptive analysis found benign tumor-associated adipose tissue exhibited higher average grey value of GRP78 staining intensity than ccRCC-associated adipose tissue (Fig 6), it is not reasonable to deduce weak GRP78 staining intensity (as demonstrated by higher average grey value) is related to a better prognosis, due to an even weaker GRP78 staining intensity that was found in grade 4 ccRCC tumor-associated adipose tissue (Fig 7).