Regarding the metastatic discrimination potential, for one unit increase in average grey value of GRP78 staining intensity in perinephric adipose tissue, the odds of ccRCC being diagnosed with distant metastasis increased by 17% (95% CI: 0.99 to 1.38, AUC = 0.73, Fig 5E). Here, HSPA5 is linked to nonpapillary renal cell carcinoma.