HSPA5 and neoplasm: Under both quantification methods, the difference in GRP78 expression between tumor renal and paired non-neoplastic renal tissue was modest (staining intensity method: mean difference = -0.74, (95% CI: -1.67 to 0.19, p = 0.12; positive pixel method: mean difference = 0.03, 95% CI: - 0.003 to 0.06, p = 0.07; Table 2).