Fig 5 (S23 Table) shows that a majority of HLA alleles, including HLA-DRB1*15:01, were inferred to exist in multiple ancestries and could thus be considered cosmopolitan. African American cases were not significantly European at the class II region compared to controls likely due to the contribution of the common African allele HLA-DRB1*15:03. In Asian Americans, HLA-DRB1*15:01 and HLA-C*03:01 conferred risk of MS and accounted for 68.6% of HLA alleles associated with MS. Here, HLA-DRB1 is linked to myeloid sarcoma.