Several recurrently mutated single nucleotide variants with previously described associations with prostate cancer and/or metastatic phenotypes, such as NOS2 [8], CTNND2 [9], and VEGFB [10], were not found to be significantly mutated at the gene level yet nevertheless are estimated to have remarkably high selection intensities, illustrating that there is much yet to learn about the potential translationally relevant genetic basis of some prostate cancers with additional tumor sequencing and even larger sample sizes. The gene discussed is NOS2; the disease is Familial prostate cancer.