Consistent with a role for SmCB1 activity in driving TH2 responses in mice, K11777 treatment reduced the frequency of eGFP+ CD4+ T cells in the spleens of infected mice at 4 weeks post infection (Fig 1D), and reduced the titers of worm-specific IgE in the plasma of infected mice (Fig 1E). The gene discussed is CD4; the disease is infection.