IBSP and non-small cell lung carcinoma: In 2006, another retrospective case–control study reported that BSP protein expression was positively associated with higher risk of BM progression and may be a useful predictor in identifying a high-risk population in the primary resected NSCLC.[14] In a retrospective cohort study published in 2009, Sekine et al[20] found that multiple BM was strongly correlated with increased risk of SREs in advanced NSCLC.