INS and type 2 diabetes mellitus: Inflammation is closely related with insulin-resistance, due to excess fat tissue producing pro-inflammatory adipokines, which results in low-grade chronic inflammation, impairing tissue response to insulin and leading to type 2 diabetes (T2DM).(4,5) HbA1c levels >7% are associated with a higher risk of irreversible, organic injuries, but HbA1c is not predictive of inflammatory processes.(1,6)