In addition, we observed enrichment of pathway in angiogenesis upon silencing PKD2 or PKD2&3, supports the current notion that PKD2 or PKD2&3 was involved in tumor blood vessel formation of breast cancer.30 Silencing PKD2 or PKD2&3 also led to enrichment of other cancer‐related pathways, for example, insulin signaling pathway, which is documented to play important role in neoplasia via modulating both cancer growth and metastasis.31 It's worth to further investigate how PKD2 or PKD2&3 functions in energy metabolism events in breast cancer. Here, INS is linked to breast cancer.