Finally, we found that additive effects of silencing both PKD2 and PKD3 compared to silencing PKD2 and PKD3 alone in proliferation and migration of breast cancer cells, and noticeable differences in the outputs of phosphoproteomes and transcriptomes among the breast cancer cells with silencing PKD2, PKD3, and both PKD2 and PKD3 (Figures 2, 3, 4, 5). The gene discussed is PKD2; the disease is breast cancer.