LGALS4 and Alzheimer disease: A group of upstream activation sequence (UAS)-driven RNA interference (RNAi) transgenes targeting genes known to be involved in ageing (Supplementary Table 1) were crossed into the AD model fly Elav-Gal4; UAS-Aβ42, which expresses Aβ42 in the central nervous system (CNS) (Elav-Gal4 specifically directs UAS-fused gene expression in the CNS, Supplementary Fig. 1a)22.