Notably, in lung cancer and mesothelioma cells, both characterized by high AKT activity, AKT inhibition prevented Ser941 RBL2/p130 phosphorylation and was associated with increased RBL2/p130 levels and stability, suggesting a role for AKT in inhibiting RBL2/p130 function [3]. Here, AKT1 is linked to mesothelioma.