THBS1 and malignant colon neoplasm: Another study showed that miR‐192 and miR‐215 were significantly reduced in a variety of colon cancer samples, acting as effectors of the tumor suppressor p53 gene 7, whereas p53‐responsive miR‐194 inhibits tumor by binding with the 3′ UTR of the THBS1 gene, which encodes an endogenous inhibitor of angiogenesis, thrombospondin‐1, and thus promotes angiogenesis in colon cancer 8.