On the other hand, alcohol and tobacco-related SCCHN (basal like, classical, mesenchymal and part of atypical) are more likely to be chemo- and radio-resistant; they often harbor high number of mutations, among which TPF5 and CCND1 (the gene encoding for Cyclin D1) are particularly interesting [15–18]. Here, CCND1 is linked to head and neck squamous cell carcinoma.