The two other variants, NM_000493.3:c.256G>A (p.G86R) in the COL10A1 gene and NM_024301:c.427C>A (p.R143S) in the FKRP gene (See Table 2), did not cosegregate with the phenotype of suspected HSP in this family, as they were similarly detected in both affected daughters and their unaffected parents. Here, FKRP is linked to hereditary spastic paraplegia.