In Panc-1 cells the decrease was very modest, but in the other tested cell lines the reduction in survivin protein was substantial, especially in Burkitt’s lymphoma cell lines Raji and Ramos, CML cell line K562, melanoma line WM-115, and renal cancer cell lines ACHN, Caki-1 and Caki-2. The gene discussed is BIRC5; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.