Additionally, baicalein was reported to inhibit receptor activator of NF-κB ligand (RANKL) and, contrarily, induce tartrate-resistant acid phosphatase (TRAP)-activity and thereby has an impact on osteoclastogenesis and bone resorption in bone erosive diseases in general [14] and rheumatoid arthritis in particular [15, 16]. The gene discussed is ACP5; the disease is rheumatoid arthritis.