Therefore, in this study, we have examined whether markers of insulin resistance, inflammation, and non-alcoholic fatty liver disease could mediate the association between RBP4 and type 2 diabetes (model 2 of Table 2), our study and other previous studies [16, 17] showed that the association between RBP4 and diabetes remained significant in women after adjusting for markers of insulin resistance (HOMA-IR, random insulin levels), inflammation (hs-CRP), and liver enzymes (Gamma-glutamyltransferase, ALT). This evidence concerns the gene MAP3K14 and type 2 diabetes mellitus.