Furthermore, high PD-L1 was also associated with a more “anti-tumour” M1-like phenotype as evidenced by the significantly higher gene expression signature score (p=<0.0001) [53] and a significantly lower ratio of CD68/CD8 gene expression (p= <0.0001) [54] (Figure 5(c)). The gene discussed is CD8A; the disease is neoplasm.