CD274 and neoplasm: This appears to be of clinical importance while high PD-L1 expression was associated with improved outcome in all core types; only the tumour rich (T) cores showed significance in terms of RFS (HR 0.445 (95%CI 0.271-0.917) p= 0.0255) (Figure 4(b)) with the same trend observed for OS though not quite reaching significance potentially due to the length of follow-up data available (5yr)(Supp Fig2A).