For example, in a study evaluating the prognostic significance of FLT3-ITD in subgroups of patients with newly diagnosed FLT3-ITD-mutated AML, a threshold of mutant-to-wild-type ratio of >0.78 was significantly associated with shorter OS and disease-free survival (DFS) [18]. The gene discussed is FLT3; the disease is acute myeloid leukemia.