FLT3 and acute myeloid leukemia: Additionally, more recent evidence from a large study of the mutational landscape in adult AML identified FLT3 as one of the most commonly occurring mutations; specifically, FLT3-ITD was found to be one of the three most common drivers in patients with AML with intermediate-risk karyotypes (based on Medical Research Council classification) [23, 24], providing further support of its role as a driver mutation.