FLT3 and acute myeloid leukemia: For example, quizartinib, an oral, highly potent, and selective next-generation FLT3 inhibitor [56], significantly improved OS in a retrospective analysis in patients with FLT3-ITD-mutated AML who had relapsed after alloHSCT or after failure of second-line salvage chemotherapy compared with similar patients not treated with FLT3 inhibitors in the UK National Cancer Research Institute AML database (1988–2013) [57].