FLT3 and acute myeloid leukemia: The first (AMLSG 16–10), a single-arm, phase 2 trial (NCT01477606; ongoing, but closed for recruitment) [79], is assessing the addition of midostaurin to chemotherapy during induction and consolidation as well as single-agent midostaurin maintenance for a maximum follow-up of 1 year in patients aged 18 to 70 years with newly diagnosed FLT3-ITD-positive AML.