(http://software.broadinstitute.org/gsea/msigdb/cards/FRIDMAN_SENESCENCE_UP.html) These results echo a prior study in which Petti and colleagues overexpressed NRAS(Q61R) into a single BRAF(V600E) melanoma line and similarly observed the eventual onset of a senescence phenotype [6]. The gene discussed is NRAS; the disease is melanoma.