Thus, it is somewhat surprising that exclusion between BRAF c.1799T>A(V600E) and NRAS c.181C>A (Q61K)/NRAS c.182A>G (Q61R) mutations is so pronounced in melanoma; there is only a single melanoma tumor specimen out of 366 sequenced which harbored concurrent BRAF c.1799T>A(V600E)/BRAF c.1798G>A (V600M) and NRAS c.37G>C (G13R) mutations (TCGA-ES-A2NC sample; www.bioportal.org). Here, BRAF is linked to melanoma.