However, the overall survival was no obvious difference between high TFPI2 or TET1 transcript level and low TFPI2 or TET1 transcript level groups, moreover, different stages of CRC patients appeared no different transcript level of TFPI2 and TET1 (Fig. 10), indicated that hypermethylation of TFPI2 in CRC was an early event. The gene discussed is TFPI2; the disease is colorectal carcinoma.