TFPI2 and colorectal carcinoma: Nevertheless, our study first highlighted the epigenetic function of mono-ADP-ribosylation of H3R117 on abnormal methylation of TSG TFPI2 by impact TET1, since hypermethyaltion of TFPI2 was an early event in tumorigenesis, selectively target mono-ADP-ribosylation of H3R117 deficiency could be a feasible way to block tumorigenesis of CRC.