The bioinformatics results showed that hypermethylation of TFPI2 was a common phenomenon in CRC comparing with normal tissue according to the The Cancer Genome Atlas (TCGA), and hypermethylation of TET1 was also detected in colon cancer with respect to normal tissue, but this phenomenon was not observed in rectal cancer (Fig. 10). Here, TET1 is linked to malignant colon neoplasm.