In contrast to the correlative association between MITF and c-MYC in single-cell RNA-seq data sets on metastatic melanoma, preliminary data indicate that expression of c-MYC appears to be decoupled from MITF at the protein level in bulk MITF-low tumor cells and TERT-immortalized melanocytes (Supplementary Figures 8c and d). This evidence concerns the gene MYC and metastatic melanoma.