Since the relationship between MITF and c-MYC had not been clearly defined yet, we analyzed accessible single-cell RNA-seq data from a panel of metastatic melanomas, which showed a strong positive correlation between the expression of MITF and c-MYC transcripts in individual cells of a given heterogeneous tumor cell population and across various tumor specimens (Fig. 6f) (GSE72056) [16]. Here, MYC is linked to melanoma.