To this end, we quantitatively assessed NER as a function of MITF or GTF2H1 by UV dosage-dependent unscheduled DNA synthesis (UDS) in primary melanocytes and melanoma cells utilizing a 5-ethylene-2ʹ-deoxyuridine (EdU) incorporation assay [38], which revealed compromised repair rates under MITF as well as GTF2H1 knockdown. The gene discussed is MITF; the disease is melanoma.