To assess whether depletion of GTF2H1 recapitulates the senescence-like phenotype induced by knockdown of MITF, we utilized several independent siRNAs directed against GTF2H1, which caused a significant growth inhibition in vitro in a variety of melanoma cell lines (Fig. 4a and Supplementary Figures 5a-c). The gene discussed is GTF2H1; the disease is melanoma.