RNAi-mediated depletion of MITF in melanocytes from various donors and melanoma cells using several independent siRNAs and expression of an adenovirus-driven dominant-negative MITF mutant resulted in a substantial reduction in constitutively expressed GTF2H1 at mRNA and protein levels, in particular under conditions of serum starvation (Fig. 1h and Supplementary Figures 2d-g). Here, GTF2H1 is linked to melanoma.