Notably, at the protein level MYC appeared to be decoupled from MITF in ∼15–20% of metastatic human melanoma samples (n = 18) and melanoma cell lines (n = 7) reflected by a low MITF/MYC expression ratio in whole cell lysates as demonstrated in immunoblot analyses (Supplementary Figures 8c and d). The gene discussed is MITF; the disease is melanoma.