MITF’s impact on global transcription superimposes over TCR and prevents a formal discrimination between direct and indirect MITF-dependent effects on strand-specific repair, but RNAi-mediated repression of the TCR-specific helicase Cockayne syndrome protein B (CSB) in melanoma cells recapitulated the NER phenotype under MITF depletion associated with a marked decrease in unscheduled DNA synthesis <12 h after UVR (Supplementary Figure 9) [45]. This evidence concerns the gene ERCC6 and melanoma.