While treating both cell lines with GI254023X did not modulate proliferation rates (4, 24, 48 and 72 h) (Fig. 5a) or cell cycle distribution (after 24 h of treatment) (Fig. 5b), GI254023X-treated mouse mesothelioma cells displayed weaker migratory properties in transwell chambers as compared to vehicle-treated cells (Fig. 5c), supporting our results obtained with cells expressing ADAM10 shRNA. The gene discussed is ADAM10; the disease is mesothelioma.