The supramolecular hydrogel matrix here can relieve the enzyme protein degradation by the non-covalent immobilization and sacrifice protection by their protein-like structure, ensuring high structural stability and enzymatic capability for efficient catalysis; the tandem SOD and CPO in the hybrid nanogels endow the SCNGs with excellent ROS sensitivity and capability of significantly promoted oxidative stress of tumour cells. Here, SOD1 is linked to neoplasm.