Finally, the multifunctional SOD/CPO-loaded nanogel system (SCNG) can thus be constructed by co-loading the cascade SOD and CPO in the supramolecular nanogel structure as a simulated neutrophil lysosome, responsively converting the relatively higher level of ROS in tumour microenvironment to 1O2 for tumour therapy. This evidence concerns the gene SOD1 and neoplasm.