Analogously to Rag-1−/− mice, both non-immunized Igh−/− mice and Igh−/− mice vaccinated with either S.Tm transformants were equally susceptible to Salmonella infection (Supplementary Figure 6f-j), supporting a crucial role for SIgA in controlling the local infection and systemic spreading of the pathogen. The gene discussed is RAG1; the disease is Salmonella Infections.