It has indeed been demonstrated in a fibrosarcoma tumor system expressing a model antigen (OVA), both in vitro and in vivo, that only the exosome surface-bound form of OVA was able to elicit a strong antigen-specific CD8+ T-cell response, helper CD4+ T-cell activation, antigen-specific antibodies, and a decrease in the percentage of immunosuppressive regulatory T cells in tumors25. Here, CD4 is linked to fibrosarcoma.