EGFR and non-small cell lung carcinoma: Based on the results of the FLAURA study, first-line treatment with osimertinib is considered as one of the standard treatments for NSCLC patients with mutated EGFR. However, it was also noted that a population of patients showed intrinsic resistance and an insufficient response to osimertinib treatment, similar to that observed with other EGFR-TKIs.