CDK5 and schizophrenia: For instance, 14-3-3ε is a schizophrenia risk factor, and our data suggest that its loss will prevent dynein force production upregulation; thus, when evaluating candidate processes potentially altered by 14-3-3ε decrease, one may want to focus on those requiring high forces, such as large cargo transport, MT reorientation, etc. Similarly, CDK5 was recently shown to play an important role in proper MT orientation in the AIS18.