Leucine-rich repeat kinase 2 (LRRK2), one of the hub genes involved in mitochondrial membrane function (Figure 5A), has been reported to play a crucial role in inducing mitochondrial fragmentation by mitochondrial dynamin-related protein-1 (Drp1) in patients with Parkinson’ disease [25,26]. This evidence concerns the gene LRRK2 and Parkinson disease.