The LINC00539/ZDHHC20 locus was a suggestive hit in a GWAS of adverse metabolic response to hydrochlorothiazide, a drug commonly used to treat hypertension.32 The lead SNP in the region could also influence the expression of the long noncoding RNA LINC00539 (table e-17, doi.org/10.5061/dryad.hk07677). This evidence concerns the gene ZDHHC20 and Hypertension.