Over the follow-up time, olfactory impairment, including hyposmia and anosmia, was associated with faster global cognitive decline than normal olfactory function in basic-adjusted (age, sex, and education) and multiadjusted (additionally adjusted for APOE ε4 and practice effects) mixed-effects models (table 2 and figure 2). This evidence concerns the gene APOE and Anosmia.