PEDF is a multifunctional factor with neurotrophic, neuroprotective and antiangiogenic activities (Barnstable and Tombran-Tink, 2004; Becerra, 2006; Becerra et al., 2004; Tombran-Tink and Barnstable, 2003), and disturbances in its secretion play important roles in the pathophysiology of retinal degenerations, including AMD and retinitis pigmentosa (Chaum, 2003). Here, SERPINF1 is linked to retinal degeneration.