PEDF is a multifunctional factor with neurotrophic, neuroprotective and antiangiogenic activities (Barnstable and Tombran-Tink, 2004; Becerra, 2006; Becerra et al., 2004; Tombran-Tink and Barnstable, 2003), and disturbances in its secretion play important roles in the pathophysiology of retinal degenerations, including AMD and retinitis pigmentosa (Chaum, 2003). The gene discussed is SERPINF1; the disease is age-related macular degeneration.