It is well known that PEDF is deficient in patients with AMD (Bhutto et al., 2006; Holekamp et al., 2002; Kolomeyer et al., 2011) and other retinal dystrophic diseases (Ogata et al., 2004), suggesting that PEDF deficiencies contribute to retinal degenerations. The gene discussed is SERPINF1; the disease is age-related macular degeneration.