In light of several studies showing that p57 is a target of EZH2, the PRC2 catalytic subunit, in different cancer cell types [41–43] and in differentiating Schwann cells [44], we focused our attention on the tri-methylation of lysine 27 in histone H3 (H3K27me3), the modification catalyzed by this complex. The gene discussed is CDKN1C; the disease is cancer.