It is important to point up that, in colorectal cancer cell lines, Kcnq1ot1 is monoallelically over-expressed [73], thus indicating that the observed effects do not result from loss of imprinting, but instead, may involve a functional interaction between Kcnq1ot1 and p57 similar to the one that we have highlighted in muscle cells. Here, CDKN1C is linked to colorectal cancer.