CDKN1C and cancer: A more detailed knowledge of the complex roles of Kcnq1ot1 and of chromatin modifications at the multiple p57 regulatory regions not only will further clarify the molecular mechanisms underlying the tight and fine regulation of p57 expression in developing tissues and its silencing in over-growth diseases and cancer, but also will provide a tool for devising strategies aimed at restoring the expression of the CDK inhibitor.